Effects of Dexmedetomidine and Midazolam on Motor Coordination and Analgesia: A Comparative Analysis☆

نویسندگان

  • Mustafa Said Aydogan
  • Hakan Parlakpinar
  • Mehmet Ali Erdogan
  • Aytac Yucel
  • Muharrem Ucar
  • Mustafa Sağır
  • Cemil Colak
چکیده

OBJECTIVE We compared the effects of 2 sedative drugs, dexmedetomidine and midazolam, on motor performance and analgesic efficacy in a rat model. MATERIALS AND METHODS Rats were randomly divided into the following 4 groups on the basis of the treatment received. The first group received 83 µg/kg/min midazolam; the second, 1 µg/kg/min dexmedetomidine; the third, 83 µg/kg/min morphine; and the fourth was a control group. The rats were measured motor coordination and pain reflexes by using rotarod, accelerod, hot plate, and tail flick tests. RESULTS At all the tested speeds, the midazolam-injected rats remained on the rotarod longer than did the dexmedetomidine-injected rats. Furthermore, in the 10-minute accelerod test, the midazolam-injected rats remained for a longer duration than did the dexmedetomidine-injected rats. The latency time for the hot plate test was significantly higher at 10 minutes and 20 minutes in the dexmedetomidine group than in the midazolam group. Further, the latency time at 10 minutes for the tail flick test was greater in the dexmedetomidine group than in the midazolam group. CONCLUSIONS In this rat model, midazolam results in faster recovery of motor coordination performance when compared with dexmedetomidine.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Effect of Adding Dexmedetomidine to Lidocaine on Sensory and Motor Characteristics in Patients Undergoing Upper Extremity Fracture Surgery under Supraclavicular Block: A Randomized Controlled Clinical Trial

Background: Various drugs are used as adjuvants to improve the quality of supraclavicular block. Objective: This study aimed to investigate the effect of adding dexmedetomidine to lidocaine on the characteristics of supraclavicular block in upper limb surgeries. Methods: This double-blind controlled clinical trial was conducted on patients undergoing upper extremity fracture surgery under a ...

متن کامل

Comparison of the effects of adding dexmedetomidine versus midazolam to intrathecal bupivacaine on postoperative analgesia.

BACKGROUND Dexmedetomidine and midazolam both modulate spinal analgesia by different mechanisms, and yet, no human studies are available to compare them for postoperative analgesia after neuraxial administration. OBJECTIVES We investigated the addition of dexmedetomidine or midazolam to intrathecal bupivacaine on the duration of effective analgesia and clinical safety profile. STUDY DESIGN ...

متن کامل

Comparison Hemodynamic Effects of Midazolam and Dexmedetomidine as a Premedication in Patients Undergoing Upper Limb Surgeries: A Double-blind Intervention

Introduction: Premedication is an integral part of general anesthesia which has side effects. The aim of this study was to compare the hemodynamic effects of Dexmedetomidine and Midazolam as a premedication in patients undergoing elective upper limb surgery during induction of anesthesia and postoperative shivering. Methods: 60 candidates for elective upper limb surgery who referred to Shahid R...

متن کامل

مقایسه اثر آرامبخشی دکسمدتومدین با میدازولام در بیماران تحت اکوکاردیوگرافی مری

Background and purpose: Transesophageal echocardiography (TEE) is established as a sensitive and accurate diagnostic method for the rapid assessment of cardiovascular diseases. It is believed that dexmedetomidine might be useful for sedating patients undergoing TEE. This study compared the use of dexmedetomidine and midazolam in patients undergoing TEE. Materials and methods: In a clinical t...

متن کامل

Comparison of dexmedetomidine versus midazolam on hemodynamic parameters, bleeding, satisfaction of surgeons and patients who Underwent laminectomy surgery by spinal anesthesia

Background: One of the most empirical subjects particularly in substantial operations for example in surgeries involving the vertebral column, are the implication of sedatives in a manner which would create the least complications such as changes in the hemodynamic parameters. Two such drugs that are widely used in this capacity in clinical settings are midazolam and dexmedetomidine. Hemodynami...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 75  شماره 

صفحات  -

تاریخ انتشار 2013